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Latest EJPPS Journal Volume 23 Issue 1 available for download

18 April 2018   (0 Comments)
Posted by: Tamsin Marshall
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Latest Issue

Volume 23 Issue 1


Editorial: Managing the global suppliers

Peer Reviewed Paper : Designing of nanoparticulate systems of kappa carrageenan containing antihypertensive drug

 Author: Ankit Mishra and SK Yadav

Abstract: We explored the possible use of kappa-carrageenan ( κC) to form a nanogel to hold the antihypertensive drug metoprolol succinate (MS) for sustained release. Nanogels were prepared by two different methods: emulsification and reverse emulsification at an elevated temperature followed by phase inversion. Both the methods consistently produced hydrogels in the nano-size range. The effect of various physical cross-linking agents and the ratio of cross-linking agent to the polymer on the particle size, drug entrapment and drug release from the nanoparticulate hydrogel were studied. The nanogels prepared using potassium chloride revealed a homogeneous size distribution and superior drug entrapment efficiency. The increase in the % ratio of cross-linker to polymer was also studied and was shown to have a significant effect on drug entrapment. A maximum drug entrapment of 50% was obtained for MS in the prepared nanogels. Drug release was related to the particle size, with smaller particles releasing the drug at a significantly higher rate than larger particles. The optimised κC nanogels, with respect to size and entrapment efficiency, can, therefore, be used to sustain the release of MS.


Science and Technology Features

Rationale for the selection of microbial monitoring locations on personnel working in aseptic processing areas
Author: Ravikrishna Satyada and Tim Sandle
Abstract: The assessment of personnel working in aseptic processing areas, whether this is for supporting Grade B (ISO Class 7 in operation) or more critical Grade A (ISO Class 5) activities is an important part of the environmental monitoring programme. Guidance from regulators is limited as to how and when personnel monitoring is performed, especially in relation to the locations to be selected on the cleanroom gown. In this paper, we examine the potential sites for monitoring and provide a risk-based rationale for the most appropriate sites. The intention is not to provide a defined approach that every aseptic processing facility should adopt; instead we offer a schematic that other organisations can consider, to either base their own operator sampling regime upon or to benchmark their own monitoring regime against. This is on the expectation that regulators expect personnel monitoring locations to be defined and justified.


Parenteral pharmaceutical future: from blockbuster products to speciality medicine
Author: Gert Moelgaard


PHSS QP Forum Conference

Regulatory review 
Malcolm Holmes

PHSS activity and initiatives report

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